Still the leader of the the Powerpuff Girls. She is a bit more sensitive than her TV incarnation, but still very strong-willed. She gets kidnapped by Mandark later in the comic and develops a bit of a crush on Dexter as the comic progresses.
Dexter's relationship with Blossom is probably the most famous in the comic. Blossom soon fell in love with Dexter and gets jelous if she sees him with another girl. Dexter gets jealous if he sees Blossom with another boy. But they both like each other a lot.
When Blossom stumbles upon his makeshift lab in the school's library, Otto (from Time Squad) takes her back in time and shows her the boy genius's tragic past, which involves Mandark and Dexter's older sister Dee Dee, who died saving Dexter from a laser fired by one of Mandark's robots. Dexter later comes to Blossom's rescue when Mandark kidnaps her.
She was also jealous on Olga Ostronominov when she saw her and Dexter.